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Selective COX-2 Inhibitors: Pharmacology, Clinical Effects and Therapeutic Potential download epub

by Sir John R. Vane,Jack H. Botting


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However, over the years, it became apparent that at therapeutic doses, some NSAIDs had greater toxic side-effects than others, a fact not explained by the general theory.

However, over the years, it became apparent that at therapeutic doses, some NSAIDs had greater toxic side-effects than others, a fact not explained by the general theory. It became clear that different NSAIDs had greater or lesser effects on COX-I when used in therapeutic doses, explaining the variation in side-effects. The elucidation of the crystal structure of these different enzymes and the skills of medicinal chemists have led to the synthesis of new chemicals with a selectivity for the inducible enzyme, and thus with therapeutic efficacy without those toxic effects result­ ing from inhibition of the constitutive enzyme.

It is becoming more evident that inhibition of COX-2 results in the analgesic and anti-inflammatory actions of non-steroidal anti-inflammatory drugs (NSAIDs), and that inhibition of COX-1 results in the adverse side-effects seen with these compounds.

Botting, Jack . Vane, Sir John R. ISBN-13.

Selective Cox-2 Inhibitors : Pharmacology, Clinical Effects and Therapeutic Potential. This button opens a dialog that displays additional images for this product with the option to zoom in or out. Tell us if something is incorrect. Selective Cox-2 Inhibitors : Pharmacology, Clinical Effects and Therapeutic Potential. Botting, Jack .

oceedings{Vane1998SelectiveCI, title {Selective COX-2 inhibitors : pharmacology, clinical effects, and . 2. The Structure of Human COX-2 and Selective Inhibitors .

oceedings{Vane1998SelectiveCI, title {Selective COX-2 inhibitors : pharmacology, clinical effects, and therapeutic potential : proceedings of a conference held on March 20-21, 1997, in Cannes, France}, author {John R. Vane and Jack Howard Botting}, year {1998} }. John R. Vane, Jack Howard Botting. 3. Differential Inhibition of COX-1 and COX-2 by NSAIDs: A Summary of Results Obtained Using Various Test Systems M. Pairet, et al. 4. COX-2 in Brain and Retina: Role in Neuronal Survival .

Автор: Sir John R. Vane; Jack H. Botting; . Описание: Thus the anti-inflammatory actions of non-steroid anti-inflammatory drugs (NSAIDs) may be due to the.

Selective cyclooxygenase-2 (COX-2) inhibitors were developed to reduce .

Selective cyclooxygenase-2 (COX-2) inhibitors were developed to reduce the gastrointestinal toxicity of conventional nonsteroidal anti-inflammatory agents. However, COX-2 inhibitors decrease prostacyclin production and may disrupt the normal homeostatic balance, leading to a prothrombotic state and offsetting the potential gastrointestinal benefits. studies raise significant concern about the potential prothrombotic effect of this class of drugs. It is now believed that the NSAIDs exert their therapeutic activity through the inhibition of COX-2 at the site of inflammation.

Categories: Clinical & Internal Medicine. Therapeutic Roles of Selective COX-2 Inhibitors.

Pharmacology, Clinical Effects and Therapeutic Potential. by John R. Vane, Jack H. Botting. Published January 31, 1998 by Springer.

This volume is the proceedings of the William Harvey Research Conference held in Cannes, France, on the 20th and 21st March, 1997. It describes the present knowledge of the structures of the cyclooxygenase isoforms and the experimental and clinical effects of selective inhibitors of cyclooxygenase-2. The pathophysiological significance of the cyclooxygenase enzymes in tumorigenesis, programmed cell death, vascular disease and asthma is also covered.
Selective COX-2 Inhibitors: Pharmacology, Clinical Effects and Therapeutic Potential download epub
Medicine & Health Sciences
Author: Sir John R. Vane,Jack H. Botting
ISBN: 0792387295
Category: Other
Subcategory: Medicine & Health Sciences
Language: English
Publisher: Springer; 1 edition (January 31, 1998)
Pages: 160 pages