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Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors download epub

by Eric Wickstrom


Epub Book: 1599 kb. | Fb2 Book: 1303 kb.

A Brief History of Genetic Therapy: Gene Therapy, Antisense Technology, and Genomics, James W. Hawkins Preclinical Development of Oligonucleotide Therapeutics for Cancer: Regulatory Aspects, Chang-Ho Ahn and Joseph J. DeGeorge Commercial Scale Manufacturing o. .

A Brief History of Genetic Therapy: Gene Therapy, Antisense Technology, and Genomics, James W. DeGeorge Commercial Scale Manufacturing of Oligonucleotides Under Good Manufacturing Practices, Jose E. Gonzalez, Richard G. Einig, Patricia Puma, Timothy . oonan, Paul E. Kennedy, Bruce G. Sturgeon, Bing H. Wang, and Jin-yan

discusses both synthetic DNA and biological vector approaches to cancer, viral, and cardiological indications. illustrates for new practitioners how each stage of genetic therapy is developed.

discusses both synthetic DNA and biological vector approaches to cancer, viral, and cardiological indications. details genetic treatment of leukemia; lymphoma; cancer of the brain, breast, colon, kidney, and lung; melanoma; HIV; and coronary restenosis. includes examples of antisense, ribozyme, tumor suppressor, immunostimulation, and gene replacement therapy. and addresses questions of preparation, delivery, toxicity, mechanism, and specificity.

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In Antisense s and Antisense RNA as Novel Pharmacological and Therapeutic Agents (Weiss, . e., CRC Press, Boca Raton, FL, pp. 58–78.

Marcel Dekker, New York. In Antisense s and Antisense RNA as Novel Pharmacological and Therapeutic Agents (Weiss, . 26. Agrawal, S. and Zhang, R. (1997) Pharmacokinetics of oligonucleotides.

CpG-containing immunostimulatory DNA sequences (ISS), which signal through TLR9, are being developed as a therapy for allergic indications and have proven to be safe and well tolerated in humans when administrated via the pulmonary route. In contrast, ISS inhalation has unexplained toxicity in rodents, which express TLR9 in monocyte/macrophage lineage cells as well as in plasmacytoid DCs (pDCs) and B cells, the principal TLR9-expressing cells in humans.

Highlights official Food and Drug Administration positions on the preparation of oligonucleotides and vectors.

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Immune Cell Involvement in Anti-c-myc DNA Prevention of Tumor Formation in a Mouse Model of Burkitt'S Lymphoma. Gray, Robert Townsend, Haruko Hayasaka, Robert Korngold, Eric Wickstrom.

J Clin Oncol1996;14:1320–6. OpenUrl Abstract/FREE Full Text.

Scientists, led by Eric Wickstrom, PhD, professor of.

An important new collection of clinical and preclinical reports on genetic therapy, this book describes illustrative examples of diseases in which gene-based interventions are presently plausible, and presents case studies of current research using both synthetic oligonucleotides and biological vectors. Combining the insights of over 50 contributors, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectorsfurnishes a historical overview of genetic therapy highlights official Food and Drug Administration positions on the preparation of oligonucleotides and vectors offers practical models of agent preparation, animal testing, pharmacokinetics, toxicology, and clinical trials discusses both synthetic DNA and biological vector approaches to cancer, viral, and cardiological indications illustrates for new practitioners how each stage of genetic therapy is developed details genetic treatment of leukemia; lymphoma; cancer of the brain, breast, colon, kidney, and lung; melanoma; HIV; and coronary restenosis includes examples of antisense, ribozyme, tumor suppressor, immunostimulation, and gene replacement therapy and addresses questions of preparation, delivery, toxicity, mechanism, and specificity.
Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors download epub
Medicine & Health Sciences
Author: Eric Wickstrom
ISBN: 0824700856
Category: Other
Subcategory: Medicine & Health Sciences
Language: English
Publisher: CRC Press; 1 edition (April 21, 1998)
Pages: 448 pages