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Cholesterol Metabolism, Ldl, and the Ldl Receptor download epub

by N. B. Myant


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Considerable chapters are devoted to LDL receptor and its pathway.

Considerable chapters are devoted to LDL receptor and its pathway. The concluding chapter deals with the clinical consequences of genetic dysfunction of the LDL receptor, with particular emphasis on the diagnostic and treatment approaches of familial that are based wholly or in part on knowledge of the LDL receptor or its gene. This book is an indispensable guide for biologists, physiologists, and clinicians who are interested in the epidemiological field of cholesterol and heart attacks.

eBook ISBN: 9780323148870. Imprint: Academic Press. This book is organized into 10 chapters that describe the coordinated actions of three regulated processes, namely, the intracellular synthesis of cholesterol, its esterification by ACAT, and the receptor-mediated uptake of low-density lipoprotein (LDL), for optimal level of free cholesterol. The first five chapters explore the various aspects of cholesterol biology, including discussions on the interaction of ligands with their cell-surface receptors; the role of coated pits in the endocytosis of receptor-bound ligands; and the recycling of receptors through the interior of the cell.

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Regulation of plasma cholesterol levels via LDL receptor-mediated uptake and HDL-mediated reverse transport. All three SREBPs are proteolytically activated and the proteolysis is controlled by the level of sterols in the cell. Regulation of HMGR activity is the primary means for controlling the level of cholesterol biosynthesis. The enzyme is controlled by four distinct mechanisms: feed-back inhibition, control of gene expression, rate of enzyme degradation and osphorylation.

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cells are exposed to whole serum containing low density lipoprotein (LDL) (3, 4). The enzymatic site of this . These keywords were added by machine and not by the authors

cells are exposed to whole serum containing low density lipoprotein (LDL) (3, 4). The enzymatic site of this suppression in human fibroblasts has been localized to utaryl coenzyme A reductase (HMG CoA reductase), the same enzyme that limits the rate of cholesterol synthesis in liver (3, 4). Keywords. Cholesteryl Ester Cholesterol Synthesis Familial Hepatic Cholesterol Synthesis Nonhepatic Tissue. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves

The binding of LDL and the receptor in the hepatocyte surface triggers an endocytosis process . The cholesterol, fatty acids and amino acids released from the LDL hydrolysis can be used in cell metabolism.

The binding of LDL and the receptor in the hepatocyte surface triggers an endocytosis process ( docytosis ), with the formation of endosomes. Changes in Ph provoke the dissociation between the lipoprotein and the receptor, the receptor returns to the membrane while the endosome fuse with a lysosome; lysosome enzymes hydrolyze the LDL proteins, the cholesterol esters and other lipids.

Items related to Cholesterol Metabolism, LDL, and the LDL Receptor. N. B. Myant Cholesterol Metabolism, LDL, and the LDL Receptor. ISBN 13: 9780124145689. ISBN 10: 012414568X ISBN 13: 9780124145689. Customers who bought this item also bought. 1. Published by Academic Press.


Cholesterol Metabolism, Ldl, and the Ldl Receptor download epub
Biological Sciences
Author: N. B. Myant
ISBN: 0125123000
Category: Science & Math
Subcategory: Biological Sciences
Language: English
Publisher: Academic Pr (July 1, 1990)
Pages: 450 pages