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The Logic of Chemical Synthesis download epub

by Xue-Min Cheng,E. J. Corey


Epub Book: 1746 kb. | Fb2 Book: 1877 kb.

These syntheses are the result of synthetic planning which was based on the general principles summarized in Part One. Thus, Part Two serves to supplement Part One with emphasis on the reactions of synthesis and on specific examples of retrosynthetically planned syntheses.

These syntheses are the result of synthetic planning which was based on the general principles summarized in Part One. Part Three is intended to balance the coverage of Parts One and Two and to serve as a convenient guide to the now enormous literature of multistep synthesis.

The logic of. Chemical synthesis. E. j. corey and xue-min chelg. Department of Chemistry Harvard University Cambridge, Massachusetts. John wiley & sons. The title of this three-part volume derives from a key theme of the bookthe logic underlying the rational analysis of complex synthetic problems. Although the book deals almost exclusively with molecules of biological origin, which are ideal for developing the fundamental ideas of multistep synthetic design because of their architectural complexity and variety, the approach taken is fully applicable to other types of carbon-based structures.

J. Corey, Xue-Min Cheng. A new and powerful approach to the synthesis of complex organic molecules

J. A new and powerful approach to the synthesis of complex organic molecules. First part of this book presents the general principles of synthetic problemsolving, including the method of systematic retrosynthetic analysis, and the concurrent use of multiple independent strategies. Second part provides details of many specific syntheses, all of which have been tested in the lab. Third part comprises a comprehensive guide to the literature of multistep synthesis. ISBN: 978-0-471-11594-6 June 1995 456 Pages.

Other readers will always be interested in your opinion of the books you've read. Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them. 1. The logic of quantum mechanics.

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Among his books are "The Logic of Chemical Synthesis", "Molecules and Medicine", and "Enantioselective Chemical Synthesis".

oceedings{Corey1989TheLO, title {The Logic of Chemical Synthesis}, author {E. Corey and Xue-min Cheng}, year {1989} }. Part 1 General approaches to the analysis of complex synthetic problems: the basis for retrosynthetic analysis transform-based strategies structure-based and topological strategies stereochemical strategies functional group-based and other strategies concurrent use of several strategies.

Logic of Chemical Synthesis Corey 1989. Folkscanomy: A Library of Books. Additional Collections. Uploaded by Sketch the Cow on February 8, 2016. ark:/13960/t5fb93v7w.

Unlike the Nicoloau approach in Classics in Total Synthesis, retrosynthetic analysis of these complex targeting molecules is omitted. The book also skips all the reaction intermediates and reaction mechanisms. A good way to understand the syntheses would be to go backward and make sense out of each step.

The Logic of Chemical Synthesis The title of this three-part volume derives from a key theme of the book-the logic underlying the rational analysis of complex synthetic problems. Although the book deals almost exclusively with molecules of biological origin, which are ideal for developing the fundamental ideas of multistep synthetic design because of their architectural complexity and variety, the approach taken is fully applicable to other types of carbon-based structures. Part One outlines the basic concepts of retrosynthetic analysis and the general strategies for generating possible synthetic pathways by logical reduction of molecular complexity. Systematic retrosynthetic analysis and the concurrent use of multiple independent strategies to guide problem solving greatly simplify the task of devising a new synthesis. This way of thinking has been used for more than two decades by one of the authors to teach the analysis of difficult synthetic problems to many hundreds of chemists. A substantial fraction of the intricate syntheses which have appeared in the literature in recent years have been produced by these individuals and their students. Part Two, a collection of multistep syntheses, provides much integrated information on synthetic methods and pathways for the construction of interesting target molecules. These syntheses are the result of synthetic planning which was based on the general principles summarized in Part One. Thus, Part Two serves to supplement Part One with emphasis on the reactions of synthesis and on specific examples of retrosynthetically planned syntheses. Part Three is intended to balance the coverage of Parts One and Two and to serve as a convenient guide to the now enormous literature of multistep synthesis. Information on more than six hundred interesting multistep syntheses of biologically derived molecules is included. It is hoped that the structural range and variety of target molecules presented in Part Three will appeal to many chemists.

Comments: (7)

Chuynopana
This book is directed towards graduate students or more experienced researchers. It would not be suitable for any but the most advanced undergraduate students.

The first 100 pages (Part I) set forth the logic of retrosynthetic analysis generally, then with examples of the application of major retrosynthetic strategies((transform-based, stereochemical, functional group, and combination) dissected in some detail. Part II (150 pages) consists of many examples of complex syntheses with reaction schemes, which were designed using retrosynthetic analysis, but without description or analysis of he retrosynthetic analysis. Part III (75 pages) is simply a list of complex naturally occuring molecules which had been synthesized, with literature references. There is no description of the retrosynthetic analysis, or the synthetic pathway.

There is no discussion of computer-based retrosynthetic analysis, such as Dr. Corey's LHASA program.
Zymbl
very good book
Bajinn
Dr Corey is the truth, an so was his books. This one is an official guide of "how to make a nice retrosynthetic analysis."
Xisyaco
Great book
Ylonean
Organic chemists and practicing researchers would agree that this book goes hand-in-hand with Nicoloau's Classics in Total Synthesis. While the latter discusses the total synthesis of some of the most fascinating molecules from all over the world, The Logic of Chemical Synthesis is a collection of E. J. Corey's (winner of 1990 Nobel Prize in Chemistry) total syntheses. The book deals almost exclusively with molecules of biological origin.
Part 1 of the book discusses the basic concepts of retrosynthetic analysis. Subtopics include transform-based strategies, structure-based strategies, topological strategies, stereochemical strategies, functional group-based strategies, and convergence of such strategies. Many examples are provided to illustrate these strategies. Molecules shown include Longifolene, Porantherine, Gibberellic acid, Picrotoxinin, and Ginkgolide B. The strategies help generate possible synthetic pathways by logical reduction of molecular complexity. In more plain words, the section help dissect complex molecules and reduce them into smaller precursors.
Part 2 focuses on how to apply the synthesis strategies from Part 1 in synthetic methods and pathways for the construction of many complex target molecules. The syntheses combine general principles presented in Part 1 and further enforces idea of retrosynthetic analysis by showing specific examples and emphasizing on reactions of synthesis. The section breaks down into macrocyclic structures, heterocyclic structures, sesquiterpenoids, polycyclic isoprenoids, prostanoids, and Leukotrienes. The syntheses presented here might be somewhat more difficult to comprehend at first sight. E. J. Corey here presents the straightforward synthesis of molecules without any didactic explanations and comments. Unlike the Nicoloau approach in Classics in Total Synthesis, retrosynthetic analysis of these complex targeting molecules is omitted. The book also skips all the reaction intermediates and reaction mechanisms. A good way to understand the syntheses would be to go backward and make sense out of each step.
Part 3 deals with current chemical literature pertaining to multistep syntheses. The book assumes knowledge of at least one course in organic syntheses which emphasize on synthetic strategies and named reactions.
Dranar
This text is a wonderful insight into the mind and chemical synthetic strategies of E. J. Corey. However, it is really not a good tool for beginning students. The sections on synthons and retrosnthetic strategies are fairly useful for beginners, but the majority of the text are the examples of total syntheses from Corey's work. While these are greatly useful as an insight into Corey and complex synthesis, it is not the best book for beginning students. Too often the routes Corey uses/used involve rare and expensive reagents, seldom the first choice in most labs. Students who start with this text are often confused when approaching a problem in a more realistic (cost concerned) environment and are confused as to what should be the first attempt at a particular transformation--Corey often tells what worked without mentioning what else was tried first, suggesting to the beginning student that the route ultimately used was the first choice, which often is not the case. Long story short, for advanced students or professors of chemistry this is an ideal text, but it is not something a beginning graduate student wants to study without a great deal of other sources.
Arashilkis
This is an extraordinarily well-written book which may be used as a learning tool for the starting Organic synthetic chemist, who, with no doubt, will enjoy himself by going through it. Many references are given after each synthesis, so that the reader can refer to specific journals and find out the actual reaction conditions that were carried out for each synthesis. Also, at the end of the book, a list of several natural products and their classical preparations are given with their respective journal citation. I believe that this book provides the organic syntehtic chemist with a feel for the area and its boundless applications and limits. I would recommend this book to anybody engaged in some kind of synthetic work, since there is good chance that this book will have the answer to some of their questions.
As a synthetic chemist, I consider this book as a masterpiece
The Logic of Chemical Synthesis download epub
Chemistry
Author: Xue-Min Cheng,E. J. Corey
ISBN: 0471509795
Category: Science & Math
Subcategory: Chemistry
Language: English
Publisher: Wiley-Interscience; 1 edition (March 28, 1989)
Pages: 436 pages